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If this happens, you can either turn off drop shadows or switch the display to either 256 colors or millions of colors and the distortion will not occur.
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With some video cards set to display thousands of colors, you may notice that label shadows are distorted or have the wrong colors. Printers connected to a serial port or using a Serial-to-USB adapter are NOT supported. The LabelWriter 300, 330, and 330 Turbo printers mentioned in the list above are only supported when connected through a USB port on your Mac computer. DYMO Labelwriter for the dedicated Dymo label and tape maker machines, supports the following printer models:
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